M. Sc. Kai Grenningloh
be developed fast and administered safely. [1] The mRNA can be engineered, e.g., as part of a vaccine to instruct the patient’s immune system to defend itself against infectious diseases (e.g. CoViD-19) [...] as RNases in the bloodstream would break it down in a fraction of a second. Thus, a drug delivery system is necessary to protect the mRNA and help it reach the patient’s cell where it can then perform as [...] the desired API. Lipid Nanoparticles (LNPs, see Fig. 2) can act as such a delivery and protection system for mRNA. These particles contain ionizable lipids that are cationically charged at low pH. Thus …